In early 2016, Charlie is a super-morbidly obese recluse in Moscow, Idaho. Weighing 600 pounds (270 kg), Charlie never leaves his apartment, where he teaches online English writing courses to college students, but keeps his webcam off, ashamed of his appearance. His nurse Liz enables him by bringing him unhealthy food, while urging him to seek treatment for heart failure, though Charlie insists he cannot afford medical care. Charlie orders pizza almost every night with delivery driver Dan, who leaves pizza on the porch and collects payment from the mailbox, the two never meeting face-to-face. Things begin to change for Charlie when he is visited by Thomas, a missionary for the New Life Church who wants to help him. Thomas learns that Charlie hopes to reconnect with his estranged teenage daughter Ellie, whom he abandoned eight years before when leaving his wife, Mary, for a male student of his, Alan. He reveals that he has been saving money for years and offers Ellie his $120,000 bank account if she spends time with him. Ellie agrees on the condition that he completes her homework, though he also requests that she write in a notebook he gives her. As Charlie's health worsens, Liz brings him a wheelchair. Thomas again visits Charlie. Liz arrives and angrily orders Thomas to leave, then changes her mind and has a talk with him outside. Liz chastises Thomas for his efforts to help Charlie, then reveals she is the adopted daughter of New Life's head pastor and that Alan was her brother; Alan's religious guilt drove him to suicide, and Charlie turned to emotional eating to cope with his grief, leading to his current weight. Despite Liz's objections, Thomas still believes his mission is to help Charlie. One day, Ellie places crushed Ambien into Charlie's food, knocking him out. Thomas arrives, and the two smoke marijuana. Thomas confesses to stealing money from the church and running away because he was dissatisfied with the mission work in Iowa. Ellie secretly records their conversation. Liz brings Mary to visit Charlie. When Liz learns about the amount Charlie has saved for Ellie, she storms out, furious over having been lied to about why he avoided medical treatment. Mary and Charlie argue over his decision to leave his family for Alan. Mary is further exasperated with Ellie's apparently malevolent behavior, but Charlie expresses hope that Ellie will prove he did "one thing right with his life". Later, after delivering pizza, Dan hears Charlie suffer a coughing fit and waits outside to ensure he is okay. When Charlie comes outside to get the pizza, Dan sees his appearance for the first time and abruptly leaves in shock. Humiliated and devastated, Charlie spirals into a severe binge-eating episode and sends a profanity-laden email to his students, telling them to disregard the classwork and write him back "something honest". Thomas visits Charlie to inform him that he is moving back home after Ellie sent his confession to his church and family, who have forgiven him and implored him to return. He attempts to preach Romans 8:13 to Charlie, but Charlie chastises him when he attributes Alan's death to his sexual orientation and orders him out. During his next class, Charlie tells his students he is being fired for the email he sent, and reads some of their submissions. To reciprocate their honesty, he switches on his webcam, and the students have mixed reactions. Charlie proclaims that college does not matter, but the honest things his students have written do. He then ends the class by tossing his laptop against the fridge. Liz returns and comforts a dying Charlie. Ellie arrives to confront him over the failing grade she received on an essay he supposedly rewrote for her, which he secretly replaced with an essay she wrote in eighth grade about Moby-Dick that he considers the most honest essay he has ever read. Ellie initially rebukes him as he attempts to reconcile one final time, but reads the paper aloud at Charlie's insistence. Charlie stands up and walks toward her without assistance. As she finishes reading, they smile at each other. 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